Giovanna Mantovani Selected Research

Pituitary ACTH Hypersecretion

1/2022	Molecular mechanisms involved in somatostatin receptor regulation in corticotroph tumors: the role of cytoskeleton and USP8 mutations.
8/2021	Genetic Profiling of a Cohort of Italian Patients with ACTH-Secreting Pituitary Tumors and Characterization of a Novel USP8 Gene Variant.
1/2021	USP8 inhibitor RA-9 reduces ACTH release and cell growth in tumor corticotrophs.
1/2019	Somatostatin analogs regulate tumor corticotrophs growth by reducing ERK1/2 activity.
5/2017	Hypercoagulability in patients with Cushing disease detected by thrombin generation assay is associated with increased levels of neutrophil extracellular trap-related factors.
9/2014	Activation of the dopamine receptor type-2 (DRD2) promoter by 9-cis retinoic acid in a cellular model of Cushing's disease mediates the inhibition of cell proliferation and ACTH secretion without a complete corticotroph-to-melanotroph transdifferentiation.

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Giovanna Mantovani Research Topics

Disease

36	Neoplasms (Cancer) 06/2023 - 12/2004
35	Pseudohypoparathyroidism 10/2023 - 09/2003
22	Pituitary Neoplasms (Pituitary Adenoma) 08/2023 - 10/2003
9	Neuroendocrine Tumors (Neuroendocrine Tumor) 03/2024 - 07/2013
9	Hypocalcemia 01/2024 - 01/2013
9	Obesity 10/2023 - 12/2004
8	Hypogonadism (Hypergonadotropic Hypogonadism) 05/2024 - 11/2005
6	Acromegaly 12/2022 - 01/2010
6	Pituitary ACTH Hypersecretion 01/2022 - 09/2014
5	Brachydactyly 10/2023 - 05/2015
5	COVID-19 01/2023 - 01/2020
5	Hypothyroidism 01/2022 - 09/2007
5	Adenoma (Adenomas) 01/2019 - 10/2002
4	Adrenal Insufficiency (Adrenal Gland Hypofunction) 01/2023 - 10/2012
4	Hyperphosphatemia 01/2022 - 01/2013
4	Acrodysostosis 01/2019 - 12/2012
4	Prolactinoma (Prolactinomas) 01/2019 - 04/2008
4	Familial Hypoadrenocorticism 05/2006 - 01/2002
3	Endocrine System Diseases (Endocrine Diseases) 10/2023 - 12/2006
3	Primary Hyperparathyroidism 01/2023 - 07/2013
3	Cushing Syndrome 01/2022 - 04/2017
3	Rare Diseases (Rare Disease) 02/2021 - 01/2013
3	Carcinoid Tumor (Carcinoid) 01/2021 - 07/2013
3	Progressive Osseous Heteroplasia 01/2019 - 05/2015
3	ACTH-Secreting Pituitary Adenoma 01/2019 - 09/2014
2	Adrenocortical Carcinoma 11/2023 - 01/2023
2	Overweight 01/2023 - 01/2018
2	Seizures (Absence Seizure) 01/2023 - 01/2019
2	Hypertension (High Blood Pressure) 01/2023 - 01/2018
2	Hypoparathyroidism 01/2023 - 01/2018
2	Inborn Genetic Diseases (Disease, Hereditary) 01/2023 - 03/2013
2	Hypopituitarism (Sheehan's Syndrome) 01/2022 - 10/2020
2	Virus Diseases (Viral Diseases) 01/2022 - 01/2022
2	Melanoma (Melanoma, Malignant) 01/2022 - 03/2012
2	Neoplasm Metastasis (Metastasis) 01/2022 - 09/2017
2	Carcinoma (Carcinomatosis) 01/2021 - 02/2016
2	Hyponatremia 01/2021 - 01/2013
2	Hemorrhage 10/2020 - 01/2013
2	Type 2 Diabetes Mellitus (MODY) 01/2020 - 01/2018
2	Imprinting Disorders 01/2018 - 04/2014
2	Azoospermia 02/2003 - 01/2002
1	Osteoporosis 01/2023

Drug/Important Bio-Agent (IBA)

25	Hormones (Hormone)IBA 10/2023 - 09/2003
20	Parathyroid Hormone (Parathormone)IBA 01/2024 - 05/2006
16	Proteins (Proteins, Gene)FDA Link 01/2022 - 04/2008
13	Somatostatin (Somatotropin Release-Inhibiting Factor)IBA 12/2022 - 11/2005
13	Growth Hormone (Somatotropin)IBA 01/2022 - 12/2004
11	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2023 - 10/2012
10	FilaminsIBA 11/2023 - 03/2012
10	GTP-Binding Proteins (G-Protein)IBA 01/2021 - 10/2003
8	Dopamine Receptors (Dopamine Receptor)IBA 06/2023 - 09/2014
7	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2023 - 03/2016
7	ProlactinIBA 01/2022 - 01/2010
6	Thyrotropin (Thyroid-Stimulating Hormone)FDA Link 10/2023 - 05/2006
6	Somatostatin Receptors (Somatostatin Receptor)IBA 12/2022 - 06/2015
5	Parathyroid Hormone-Related ProteinIBA 10/2023 - 12/2016
5	GonadotropinsIBA 03/2021 - 01/2002
5	Cyclic AMP-Dependent Protein Kinases (cAMP-Dependent Protein Kinase)IBA 08/2016 - 12/2004
4	Testosterone (Sustanon)FDA Link 05/2024 - 01/2019
4	pasireotideIBA 05/2022 - 01/2019
4	somatostatin receptor 2IBA 01/2021 - 04/2017
4	5-phenylpent-4-enyl-1-hydroperoxideIBA 01/2019 - 12/2004
3	Thrombin FDA Link 05/2024 - 05/2017
3	2-(4-toluidino)-6-naphthalenesulfonic acid (TNS)IBA 08/2023 - 01/2014
3	Cabergoline FDA LinkGeneric 06/2023 - 01/2019
3	CalciumIBA 01/2023 - 01/2018
3	GlucocorticoidsIBA 01/2023 - 05/2017
3	LigandsIBA 12/2022 - 04/2014
3	Biomarkers (Surrogate Marker)IBA 12/2022 - 01/2020
3	Carrier Proteins (Binding Protein)IBA 01/2022 - 03/2014
3	somatostatin receptor 5IBA 01/2022 - 01/2019
3	Growth Hormone-Releasing Hormone (Somatotropin Releasing Hormone)IBA 07/2013 - 09/2003
3	Orphan Nuclear ReceptorsIBA 05/2006 - 01/2002
2	Insulin-Like PeptidesIBA 11/2023 - 07/2021
2	beta-Arrestin 1IBA 06/2023 - 01/2022
2	ArrestinIBA 06/2023 - 01/2022
2	SteroidsIBA 01/2023 - 01/2020
2	Dexamethasone (Maxidex)FDA LinkGeneric 01/2023 - 01/2021
2	Everolimus FDA Link 01/2022 - 08/2020
2	Denosumab FDA Link 01/2021 - 09/2016
2	Calcitriol (Calcijex)FDA LinkGeneric 01/2020 - 01/2019
2	Dopamine Agents (Dopaminergic Agents)IBA 01/2020 - 01/2010
2	Octreotide (Sandostatin)FDA LinkGeneric 01/2020 - 11/2005
2	Caspase 3 (Caspase-3)IBA 01/2019 - 11/2005
2	Alkaline PhosphataseIBA 09/2016 - 01/2013
2	Dopamine (Intropin)FDA LinkGeneric 01/2015 - 02/2010
2	Tretinoin (Retinoic Acid)FDA LinkGeneric 09/2014 - 04/2008
2	Guanine NucleotidesIBA 04/2014 - 03/2014
2	Peptides (Polypeptides)IBA 04/2014 - 03/2014
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 12/2012 - 12/2006
2	Cyclic AMP (AMP, Cyclic)IBA 02/2011 - 03/2009
2	Protein Isoforms (Isoforms)IBA 03/2009 - 04/2008
2	Messenger RNA (mRNA)IBA 03/2009 - 12/2004
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2007 - 10/2003
2	RNA (Ribonucleic Acid)IBA 11/2005 - 10/2002
1	Antimitotic AgentsIBA 03/2024
1	CollagenIBA 04/2023

Therapy/Procedure

22	Therapeutics 05/2024 - 11/2010
3	Radiotherapy 01/2021 - 01/2010
2	Length of Stay 05/2022 - 01/2021